• [Archive]
• Journal of Pharmacopuncture
• pISSN : 2093-6966
• eISSN : 2234-6856
• DB Construction : 59 Issues, 667 Articles
Year
Issues
Articles
1 Title
Keywords Acute; Toxicity; Bos tures; Ursus thibetanus; Moschus; Herbal-acupuncture
Author(s) Lee, Sang-Woon; Kang, Dae-In; Jeong, Chan-Gil; Kim, Kwang-Ho; Soh, Kyung-Sun
 Abstract This experiment was carried out to study on the safety assessment of Bos tures$\small{^{\circ}{\S}Ursus thibetanus^{\circ}{\S}}$Moschus extract solution(BUM) for Herbal-acupuncture. SD rats and ICR mice were used for acute toxicity test. the results were summerized as follows; 1. In rats and mice, LD50 value could not be measured. 2. There were no abnormal finding in acute toxicity test treated BUM for Herbal-acupuncture
2 Title
Keywords
Author(s) Jeong, Min-Su
 Abstract Spiral taping shows great effectiveness in relieving musculoskeletal pains. The purpose of this research is to compare effectiveness of herbal acupuncture of Carthami semen(Honghwa) vs its cotreatment with spiral taping for the treatment of acute low back pain. The target patients were those who satisfied with all of the following conditions. 1. Those who suffered from acute low back pain but without past history of the pain in the last six weeks. 2. The pain wasn't radiated to the lower limbs and were without any neurotic symptoms. A computerized randomization was used to set the patients in two groups. The control group was consisted of 41 patients and treated with herbal acupuncture. The experimental group was consisted of 49 patients and treated with spiral taping as well as herbal acupuncture. The treatment was given two times a week and the nurses measured the ROM and VAS evaluation before every treatment. The patients wrote ODI by themselves before the first treatment and after the 3rd treatment. After three months, an interview of the patients' condition through a follow up survey was done. In terms of acute low back pain in both the control group and experimental group, significant treatment effects were found by assessing VAS, ROM and ODI. By comparing the control group and the experimental group, there was more significant improvement in the experimental group than the control group of VAS and ROM, but no significant effect was found between the groups of ODI. This study shows that the herbal acupuncture of Carthami Semen plays a significant role in relieving acute low back pain. It also shows that spiral taping of the experimental group was more highly effective. As a result, spiral taping can be used with acupunture of Carthami Semen for a highly effective treatment for acute low back pain.
3 Title
Keywords Bee Venom; Toxic; PLA2; COX-2; iNOS; AA; PGD2; PGE2; RAW 264.7 Cell
Author(s) Ha, Seang-Jong; Lee, Seong-No; Jo, Hyun-Chul; Kim, Kee-Hyun
 Abstract Objectives : The purpose of this study was to investigate the effect of Bee Venom on the lipopolysaccharide-induced expression phospholipase $\small{A_2}$, cyclooxygenase-2 and inducible nitrogen oxide synthase, and the generation of arachidonic acid, prostaglandin D2 and E2 in RAW 264.7 cells, a murine macrophage cell line. Methods : The expression of phospholipase $\small{A_2}$, cyclooxygenase and inducible nitrogen oxide synthase was determined by western blotting with corresponding antibodies, and the generation of arachidonic acid, prostaglandin $\small{D_2}$ and $\small{E_2}$ was assayed by ELISA method in RAW 264.7 cells. The non-toxic concentrations (0.1 to $\small{5\;{\mu}g/ml}$) of bee venom determined by MTT assay, were used in this study. Results : 1. Bee venom inhibited lipopolysaccharide-induced expression of phospholipase $\small{A_2}$ in a dose dependent manner after 48 hours treatment. 2. Bee venom inhibited lipopolysaccharide-induced expression of cyclooxygenase-2 in a dose dependent manner after 24 and 48 hours treatment. 3. Bee venom inhibited lipopolysaccharide-induced expression of inducible nitrogen oxidesynthase in a dose dependent manner after 48 hours treatment. 4. The generation of arachidonic acid, prostaglandin $\small{D_2}$ and $\small{E_2}$ was not much affected by the treatment of bee venom on the lipopolysaccharide-induced generation of arachidonic acid, prostaglandin $\small{D_2}$ and $\small{E_2}$ in RAW 264.7 cells.
4 Title
Keywords Bee Venom; NO; H2O2; IL-1; Raw 264.7 cell; D10S cell
Author(s) Ha, Seang-Jong; Lee, Seong-No; Jo, Hyun-Chul; Kim, Kee-Hyun
 Abstract Objectives : The purpose of this study was to investigate the effects of Bee Venom on NO, $\small{H_2O_2}$ expression induced by LPS in Raw 264.7 cells as a murine marcrophage cell line and on IL-1 expression induced by LPS in D10S cells. Methods : The expression of NO was measured by MTT Assay and IL-1 by MTS Assay. The expression of $\small{H_2O_2}$ was measured as ROS level within the cell using by FACS analysis. The non-toxic concentration(from $\small{0.1\;{\mu}g/ml\;to\;5\;{\mu}g/ml}$) of Bee Venom was determined by MTT Assay. Results : 1. Bee Venom inhibited the NO expression. The effective concentration of Bee Venom was $\small{5\;{\mu}g/ml}$ after 3 hours, 1 and $\small{5\;{\mu}g/ml}$ after 1 day and 2 days. The all concentration of Bee Venom inhibited the NO expression after 6, 12 hours and 3 days. 2. Bee Venom inhibited the $\small{H_2O_2}$ expression in a dose-dependent manner compared to the control. 3. Bee Venom could not significantly inhibit the IL-1 expression.
5 Title
Keywords Bee venom acupuncture; Rheumatoid arthritis; quality of life; HAQ
Author(s) Lee, Sang-Hoon; Lee, Hyun-Jong; Park, Sang-Min; Kim, Su-Young; Park, Jae-Kyung; Hong, Seung-Jae; Yang, Hyung-In; Choi, Do-Young; Kim, Keon-Sik; Lee, Doo-Ik; Lee, Yun-Ho; Lee, Jae-Dong
 Abstract Objective: To evaluate the effects of bee venom acupuncture(BVA) on the rehabilitation and quality of life in rheumatoid arthritis(RA) patients Methods: Patients with RA were treated with the BVA therapy twice a week for 3 months. Tender joint counts, swollen joint counts, morning stiffness, Erythrocyte Sedimentation Rate(ESR), C-reactive protein(CRP), patient global assessment, physician global assessment, Korean health assessment questionnaire(KHAQ) were estimated and analyzed before and after BVA therapy. Results: Tender joint counts, swollen joint counts, morning stiffness showed significant decrease after BVA therapy. But, as acute inflammatory reactants, ESR showed no significant difference and CRP showed significant increase after BVA therapy. Patient global assessment, physician global assessment, and KHAQ index showed significant improvement after BVA therapy. Conclusions: BVA therapy can improve rehabilitation and health-related quality of life in RA patients as well as clinical symptoms and signs. Further study is required in more population with large scale including acute inflammatory reaction of BVA therapy.
6 Title
Keywords Dyskinesia; Dystonia; Herbal Acupuncture Therapy; to-nong-seol(吐弄舌)
Author(s) An, Chang-Suk; Yoo, Chang-Kil; Kim, Tae-Hui; Kwon, Ki-Rok; Choi, Sung-Mo
 Abstract Objective : This study was performed to evaluate the treatment of acupuncture therapy including Herbal Acupuncture in Tardive Dyskinesia. Methods & Result : We treated 1 case of Tardive Dyskinesia patient with Acupuncture and herbal Acupuncture, herbal medicine. Acupuncture therapy was taken on acupoints including CV12 (Chungwan:中脘), ST40 (Pungnyung:豊隆), SP3 (Taeback:太白). As the results of this treatments, little change of tongue motion was observed, but general conditions of the patient was improved. Conclusions : Oriental medical treatments was little effective in this disease, but general conditions of the patient was improved. We think that it need the further study and clinical trial for Tardive Dyskinesia.
7 Title
Keywords
Author(s) Lee, Joon-Moo; Lim, Kwan-II
 Abstract The lipid lowering and antioxidant effects of Gansoo(BL18), Pungji(GB20) and Eumnungcheun(SP9) acupuncture in rats fed high fat diet were analyzed in biochemical and molecular biological aspects. The results obtained from this study are as follows : 1. In the body weight reduction, all acupuncture groups showed a high reduction compared to those of control group and in acupuncture groups, Gansoo(BL18) and Pungji(GB20) acupuncture groups showed a high reduction. 2. The concentration of plasma triglyceride, total cholesterol and LDL-cholesterol with acupuncture groups showed a little decrease and in acupuncture groups, Gansoo(BL18) and Pungji(GB20) groups showed a low values compared to those of other acupuncture groups. However, the tendency of HDL-cholesterol concentration showed no significant different. 3. The concentration of plasma $\small{{\beta}-lipoprotein}$ and free fatty acids showed a lowest values in the Gansoo(BL18) and Pungji(GB20) acupuncture groups and the glucose concentration showed to decrease in all treated acupuncture groups. 4. The concentration of liver total cholesterol and triglyceride in Gansoo(BL18) and Pungji(GB20) acupuncture groups showed a lower values than those of control group. 5. In all the acupuncture groups, the plasma glutamic oxaloacetic transaminase(GOT) activity showed a little decrease. In the glutamic pyruvate activity(GPT), Gansoo(BL18) and Pungji(GB20) acupuncture groups showed a lower values than those of control groups. However the values of eumneungcheun acupuncture only group showed no significant difference to those of control group. 6. The plasma and liver Thiobabituric acid reactive substance (TBARS) concentration in Gansoo(BL18) and Pungji(GB20) acupuncture groups were a lower than those of control group. However the values of eumneungcheun acupuncture group showed no significant difference to control group. 7. The superoxide dismutase (SOD) activity in Gansoo(BL18) acupuncture group and Glutathione peroxidase (GSH-Px) activity in Gansoo(BL18) and Pungji(GB20) acupuncture groups showed a high values. The catalase (CAT) activity in all the acupuncture groups showed a higher values than those of control group. 8. In acupuncture groups, DNA expression of Apo-B and Apo-E showed a tendency to decrease, however DNA expression of leptin showed no significant difference in all treatment groups. DNA expression of $\small{TNF-{\alpha}}$ showed a increase in acupuncture groups. These results indicate that Gansoo(BL18) and Pungji(GB20) (especially Gansoo(BL18)) acupuncture affect the lipid metabolism and showed possibility of lowering adipose tissue mass and lipid peroxidation.
8 Title
Keywords
Author(s) Jang, Hae-Young; Choi, Kwan-Ho; Kim, Sung-Hyun; Kwon, Ki-Rok; Kim, Byung-Woo
 Abstract According to the bibliographic studies of Depilation, the following conditions were made after literary studies.; 1. According to the period, The depilation have been named variously, for example, Balta(髮墮), Balgu(髮去), Balrak(髮落), Mobal(毛拔), Yupung(油風), Dokchang(禿瘡), Guijidu(鬼?頭), Dokban(禿班), etc. 2. The cause of depilation was deficiency of kidney(腎虛), defciency of Qi of the lung(肺氣虛), excessive heat of blood system(血熱), deficiency of Qi and blood system(氣血虛), deficiency of blood system(血虛), and endogenouse cause of, etc. 3. The depilation is meaning fallen hair in head. There are multiform type in the symptoms of depilation; round shape, ellipse type & bald head. 4. The herbal treatment was used Yukmijihwaghwan(六味地黃丸), Palmihwan(八味丸), Singihwan(腎氣丸), Hwangigunjungtang(黃耆建中湯), Samultang(四物湯), ect. and external herbal reatment was Sineungyangjindan(神應養鎭丹), Bangpungtongsungsan(防風通聖散), ect.
9 Title
Keywords Klippel-Trenaunay-Weber Syndrome; Korean Bee Venom Theraphy; Herbal Acupuncture Therapy; Acupuncture Therapy
Author(s) Yoo, Chang-Kil; An, Chang-Suk; Kang, Kye-Sung; Cho, A-Rha; Kwon, Ki-Rok; Kim, Byung-Woo
 Abstract Objective : This study was performed to evaluate the treatment of Acupuncture therapy including Herbal Acupuncture theraphy and Korean Bee Venom Theraphy in Klippel-Trenaunay-Weber Syndrome. Methods : We treated 1 case of Klippel-Trenaunay-Weber Syndrome patient with mainly Korean Bee Venom Theraphy, and herbal Acupuncture, acupuncture theraphy from 27th August, 2001 to February, 2003. Results : After 3 weeks of Korean Bee Venom Theraphy, and herbal Acupuncture, acupuncture theraphy, a remarkable improvement was made for Klippel-Trenaunay-Weber Syndrome. Conclusions : Korean Bee Venom Theraphy and other acupuncture therapies were effective in reducing the symptoms. We think that it need the further study and clinical trial for Klippel-Trenaunay-Weber Syndrome.
10 Title
Keywords Chemical reaction; Functional group; medicinal substance
Author(s) Choi, Sung-Mo; Kim, Byeong-U
 Abstract Objective : This study was designed to show the possible functional groups from the herb medicine in boiling water. Results : The results are summarized as follows: 1. the new functional groups can be synthesized in water solution for herb medicine. 2. The boiling water solution may change the poison materials into harmless materials. 3. The multiplication, the offset, the contradiction, etc. in terms of mixed herb medicine can be explainable by these reactions. 4. After finding the new medicinal substances for the specific disease, we can synthesize, modify, and mass produce those for that disease.
11 Title
Keywords H herbal-acupuncture; LD50; acute toxicity; subacute toxicity; Natural killer cell activity; In interleukin-2 productivity
Author(s) Kim, Tae-Hui; Kwon, Ki-Rok; Lee, Seon-Goo
 Abstract Objectives : The purpose of this study is to investigate Acute and Subacute Toxicity, and Anti-cancer Effect of H Herbal-acupuncture on mice and rats. Methods : Balb/c mice were injected intraperitoneally with H Herbal-acupuncture for $\small{LD_{50}}$ and acute toxicity test. Sprague-Dawley rats were experimented in the same way for subacute toxicity test. H Herbal-acupuncture was injected into abdomen of mice having S-180 cancer cell line. Result : 1. During the test, $\small{LD_{50}}$ could not be counted since there was no expired subjects. 2. In an acute toxicity test, the loss of motility and reflex action was observed, but weight increased in the treatment group, compared with those in the normal group (P<0.05). 3. In an acute toxicity test of serum biochemical values of mice, glucose increased in the treatment group II while total cholesterol was increased in the all treatment groups (P<0.05). 4. In a subacute toxicity test, a little loss of motility and reflex action was observed in the treatment group. Weight of mice in the treatment group decreased on the 28th day. 5. In a subacute toxicity test, liver weight was decreased but lung weight of mice increased in the all treatment groups (P<0.05). 6. As a result of measuring Complete Blood Count test (CBC) of rat, HCT was decreased in treatments even though it was not significant, compared with the normal group (P<0.05). 7. In a serum biochemical value test of subacute toxicity, total protein and albumin decreased in the all treatment groups. Creatinine, glucose, GOT increased in the treatment group I compared with the control group. Alkaline phos-phatase decreased in treatment II group, compared with the control group (P<0.05). 8. Median survival time that was measured in the rats treated with sarcoma-180 cancer cell Median decreased in the treatment group, compared with the control group (P<0.05). 9. Natural killer cell activity showed significant reduction at 100:1 and 10:1 E/T ratio while it increased at 50:1 E/T ratio. It is inferred that there was an error in the experiment (P<0.05). 10. In an interleukin-2 productivity test, even though it decreased in lung cancer, and increased in abdomen cancer, but it was only a small difference (P<0.005). 11. After injecting B16F10 cell into a capillary vessel of C57BL/6 mice and generating metastasized lung cancer, the lung was examined with the naked eye. It was not possible to see metastasized cancer in the all groups on the seventh day but the cancer was viewed on the fourteenth day. The number and volume of metastasized cancer in the treatment group enlarged in the treatment group, compared with the control group. Conclusion : According to the results, H herbal-acupuncture took no effects in cancer.